Abstract
A combination of benzoxazole, phenoxyalkyl side chain, and phenoxybutyric acids was identified as a highly potent and selective human peroxisome proliferator-activated receptor alpha (PPARalpha) agonist. The synthesis, structure-activity relationship (SAR) studies, and in vivo activities of the representative compounds are described.
MeSH terms
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Allergens
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Animals
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Antigens, Plant
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Drug Design
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Heterocyclic Compounds / chemistry*
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Heterocyclic Compounds / pharmacology*
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Humans
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Hypolipidemic Agents / chemistry
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Hypolipidemic Agents / pharmacology
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Mice
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Mice, Transgenic
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Molecular Structure
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PPAR alpha / agonists*
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Plant Proteins
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Rats
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Rats, Sprague-Dawley
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Structure-Activity Relationship
Substances
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Allergens
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Antigens, Plant
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Heterocyclic Compounds
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Hypolipidemic Agents
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MALD1 protein, Malus domestica
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PPAR alpha
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Plant Proteins